Ho Tzu Nyen produces art and film projects.

In 2003, Tzu Nyen made Utama - Every Name in History is I, an installation of film and paintings about the forgotten pre-colonial founder of Singapore, was first produced for The Substation and subsequently exhibited at the 26th Sao Paulo Biennale (2004), and the 3rd Fukuoka Asian Art Triennale (2005). In 2006, a new version of the installation, featuring jigsaw puzzles manufactured from the original paintings was presented at 'Islanded' in Adam Art Gallery, New Zealand. The film was shown at various film-festivals, such as the Bangkok International Film Festival (2004) and Hong Kong International Film Festival (2006), and was voted by the film critic Alexis Tioseco in 'The Senses of Cinema' as one of the three best short films of 2004. Utama has also been transformed into a performance lecture, presented at ICA London (2005), Fringe Festival, Bangkok (2005). In 2006, the lecture was presented at Kunsten Festival des Arts, Brussels, the inaugural Singapore Theatre Festival, as well as the Rijks Akademie voor Beeldende Kunst and the Theatre Institute Nederland, in Amsterdam.

In 2005, Tzu Nyen completed 4 x 4 ­ Episodes of Singapore Art - an attempt to shift the practice of art from the manufacture of objects to the production of 'discursive events'. The project included amongst other components, four short films scripted and directed by Tzu Nyen that resurrected 4 exemplary moments in the history of art in Singapore that were broadcasted over 4 weeks on a public television channel, Arts Central. In 2006, 4 x 4 was shown at Alternative Space Loop, Seoul, Shanghai Duolun Museum of Modern Art, Tokyo Wonder Site and ARGOS, Brussels.

In 2006, Tzu Nyen unveiled The Guernica Project at ARCO, Madrid, where a 300 piece jigsaw puzzle of Pablo Picasso's Guernica. 300 members of the public were invited to bring a piece of their choice from the puzzle home on the condition they will bring the same piece back with them at ARCO 2007 next year. He also produced The Bohemian Rhapsody Project, a film where the spoken dialogue is constituted entirely by the lyrics of Queen's 1975 hit, 'Bohemian Rhapsody', and set in the former Supreme Court of Singapore. The film was at once a courtroom drama, a documentary of its own production, a record of its audition process as well as a vehicle that solicits the spectators' participation in a collective act of mental karaoke. This was presented at the Singapore Biennale (2006). Tzu Nyen has also been commissioned to produce a panoramic film, which re-enacted in a series of tableau-vivants, key moments from the pre-colonial history of Singapore, for the National Museum of Singapore. This film will be completed in December 2006.

Ho Tzu Nyen also writes on film and the visual arts, and is the Singapore Desk Editor for the magazine Art Asia Pacific (US).